About the Authors

Ulf A. Wenzel

Affiliation Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Maria K. Magnusson

Affiliations Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and MIVAC, University of Gothenburg, Gothenburg, Sweden

Anna Rydström

Affiliation Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Caroline Jonstrand

Affiliation Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Julia Hengst

Affiliation Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Malin EV. Johansson

Affiliation Department of Medical Biochemistry, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and MIVAC, University of Gothenburg, Gothenburg, Sweden

Anna Velcich

Affiliation Department of Oncology, Albert Einstein Cancer Center/Montefiore Medical Center, New York City, New York, United States of America

Lena Öhman

Affiliations Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and MIVAC, University of Gothenburg, Gothenburg, Sweden

Hans Strid

Affiliation Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and MIVAC, University of Gothenburg, Gothenburg, Sweden

Henrik Sjövall

Affiliation Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and MIVAC, University of Gothenburg, Gothenburg, Sweden

Gunnar C. Hansson

Affiliation Department of Medical Biochemistry, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and MIVAC, University of Gothenburg, Gothenburg, Sweden

Mary Jo Wick

mary-jo.wick@immuno.gu.se

Affiliation Department of Microbiology and Immunology and the Mucosal Immunobiology and Vaccine Center (MIVAC), Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Competing Interests

This work was supported by the Swedish Research Council, The Swedish Cancer Foundation, Sahlgren’s University Hospital (LUA-ALF), AFA Insurance, The Knut and Alice Wallenberg Foundation, National Institute of Allergy and Infectious Diseases (U01AI095473; the content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH), the Swedish Foundation for Strategic Research, Assar Gabrielssons Fond and The Ruth and Richard Julin Foundation. All funding sources, including AFA Insurance, had no role in study design, data collection and analysis, decision to publish, preparation of the manuscript, consultancy or patents. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MJW GCH UAW MKM HS AR. Performed the experiments: UAW MKM AR CJ JH MEVJ. Analyzed the data: UAW MKM AR CJ JH MEVJ HS GCH MJW. Contributed reagents/materials/analysis tools: AV. Wrote the paper: UAW MJW MKM AR MEVJ HS GCH. Recruitment and enrollment of patients: HS HaS LÖ. Critically reviewed the manuscript and approved the final draft: UAW MKM AR CJ JH MEVJ AV LÖ HS GCH MJW.