Exposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice

Marta García-Arevalo; Paloma Alonso-Magdalena; Junia Rebelo Dos Santos; Ivan Quesada; Everardo M. Carneiro; Angel Nadal

doi:10.1371/journal.pone.0100214

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Research Article

Exposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice

Marta García-Arevalo,

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain
⨯
Paloma Alonso-Magdalena,

Affiliations Departamento de Biología Aplicada, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain
⨯
Junia Rebelo Dos Santos,

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Departamento de Biologia Estructural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Brazil
⨯
Ivan Quesada,

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Departamento de Biología Aplicada, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain
⨯
Everardo M. Carneiro,

Affiliation Departamento de Biologia Estructural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Brazil
⨯
Angel Nadal

* E-mail: nadal@umh.es

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain
⨯

Exposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice

Marta García-Arevalo,
Paloma Alonso-Magdalena,
Junia Rebelo Dos Santos,
Ivan Quesada,
Everardo M. Carneiro,
Angel Nadal

Published: June 24, 2014
https://doi.org/10.1371/journal.pone.0100214

About the Authors

Marta García-Arevalo

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain

Paloma Alonso-Magdalena

Affiliations Departamento de Biología Aplicada, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain

Junia Rebelo Dos Santos

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Departamento de Biologia Estructural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Brazil

Ivan Quesada

Affiliations Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain, Departamento de Biología Aplicada, Universidad Miguel Hernández de Elche, Elche, Spain, Centro de Investigación Biomédica En Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain

Everardo M. Carneiro

Affiliation Departamento de Biologia Estructural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Brazil

Angel Nadal

* E-mail: nadal@umh.es

Competing Interests

Please note that co-author Angel Nadal is a member of the PLOS ONE editorial board. This does not alter the authors' adherence to PLOS ONE Editorial Policies and Criteria.

Author Contributions

Conceived and designed the experiments: AN PAM MGA EMC IQ. Performed the experiments: MGA PAM. Analyzed the data: MGA PAM JR. Contributed reagents/materials/analysis tools: AN EMC IQ. Wrote the paper: AN.

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Body weight
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Insulin
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Glucose
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Glucose metabolism
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Fatty acids
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Gene expression
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Adipose tissue
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Diet
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