About the Authors

Anthony M. D. Lee

alee@bccrc.ca

Affiliation Department of Integrative Oncology - Imaging Unit, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada

Miranda Kirby

Affiliation Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada

Keishi Ohtani

Affiliation Department of Integrative Oncology - Imaging Unit, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada

Tara Candido

Affiliation Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada

Rebecca Shalansky

Affiliation Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada

Calum MacAulay

Affiliation Department of Integrative Oncology - Imaging Unit, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada

John English

Affiliation Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada

Richard Finley

Affiliation Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia, Canada

Stephen Lam

Affiliation Department of Integrative Oncology - Imaging Unit, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada

Harvey O. Coxson

Affiliation Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada

Pierre Lane

Affiliation Department of Integrative Oncology - Imaging Unit, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada

Competing Interests

HC received $4800 in the years 2008–2012 for serving on the steering committee for the ECLIPSE project for GSK. In addition, HC was the co-investigator on two multi-center studies sponsored by GSK and has received travel expenses to attend meetings related to the project. HC has three contract service agreements with GSK to quantify the CT scans in subjects with COPD and a service agreement with Spiration Inc. to measure changes in lung volume in subjects with severe emphysema. HC was the recipient of a GSK Clinical Scientist Award in 2010. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AMDL CM JE RF SL HC PL. Performed the experiments: AMDL KO TC RS PL. Analyzed the data: AMDL MK TC RS PL. Contributed reagents/materials/analysis tools: AMDL MK PL. Wrote the paper: AMDL MK PL. Revised manuscript: AMDL MK CM JE RF SL HC PL. Gave final approval for manuscript: AMDL MK KO TC RS CM JE RF SL HC PL.