About the Authors

Markus P. Rechsteiner

markus.rechsteiner@usz.ch

Affiliation Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

Xenofon Floros

Affiliation Department of Computer Science, ETH Zurich, Zurich, Switzerland

Bernhard O. Boehm

Current address: Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore and Imperial College London, London, United Kingdom

Affiliation Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany

Lorella Marselli

Affiliation Department of Clinical and Experimental Medicine – Islet Cell Laboratory, University of Pisa, Pisa, Italy

Piero Marchetti

Affiliation Department of Clinical and Experimental Medicine – Islet Cell Laboratory, University of Pisa, Pisa, Italy

Markus Stoffel

Affiliation Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland

Holger Moch

Affiliation Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

Giatgen A. Spinas

Affiliation Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland

Competing Interests

The sponsoring of the study by Hoffmann La Roche Ltd. does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MPR XF MS GAS HM. Performed the experiments: MPR XF. Analyzed the data: MPR XF. Contributed reagents/materials/analysis tools: MPR XF BOB LM PM MS GAS HM. Wrote the paper: MPR XF GAS HM.