About the Authors
- Alessandra De Robertis
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Contributed equally to this work with: Alessandra De Robertis, Federica Mennillo
Affiliations Molecular Oncology Unit, Siena Biotech Medicine Research Centre, Siena, Italy, Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy
- Federica Mennillo
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Contributed equally to this work with: Alessandra De Robertis, Federica Mennillo
Affiliations Molecular Oncology Unit, Siena Biotech Medicine Research Centre, Siena, Italy, Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy
- Marco Rossi
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Affiliations Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy, In Vivo Pharmacology Unit, Siena Biotech Medicine Research Centre, Siena, Italy
- Silvia Valensin
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Affiliations Molecular Oncology Unit, Siena Biotech Medicine Research Centre, Siena, Italy, Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy
- Patrizia Tunici
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Affiliations Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy, In Vivo Pharmacology Unit, Siena Biotech Medicine Research Centre, Siena, Italy
- Elisa Mori
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Affiliations Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy, Data Analysis Unit, Siena Biotech Medicine Research Centre, Siena, Italy
- Nicola Caradonna
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Affiliation MET Profiling Unit, Siena Biotech Medicine Research Centre, Siena, Italy
- Maurizio Varrone
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Affiliation Department of Medicinal Chemistry, Siena Biotech Medicine Research Centre, Siena, Italy
- Massimiliano Salerno
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* E-mail: massisal67@gmail.com
Affiliations Molecular Oncology Unit, Siena Biotech Medicine Research Centre, Siena, Italy, Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy
Competing Interests
We have the following interests. All authors are employed by the Siena Biotech Medicine Research Centre. The molecules reported in the manuscript (SEN461 and the inactive analogue SEN973) are both covered by patent application (WO/2011/042145), inventors: Massimiliano Salerno and Maurizio Varrone. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
¶ These authors also contributed equally to this work
Conceived and designed the experiments: ADR FM MR SV PT MS. Performed the experiments: ADR FM MR SV PT NC MS. Analyzed the data: ADR FM MR SV PT EM NC MS. Contributed reagents/materials/analysis tools: MV. Wrote the paper: MS.