Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells

Sujoy Dutta; Case Warshall; Chirosree Bandyopadhyay; Dipanjan Dutta; Bala Chandran

doi:10.1371/journal.pone.0097580

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Open Access

Peer-reviewed

Research Article

Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells

Sujoy Dutta ,

* E-mail: sujoy.dutta@rosalindfranklin.edu

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Case Warshall,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Chirosree Bandyopadhyay,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Dipanjan Dutta,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Bala Chandran

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯

Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells

Sujoy Dutta,
Case Warshall,
Chirosree Bandyopadhyay,
Dipanjan Dutta,
Bala Chandran

Published: May 15, 2014
https://doi.org/10.1371/journal.pone.0097580

About the Authors

Sujoy Dutta

* E-mail: sujoy.dutta@rosalindfranklin.edu

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America

Case Warshall

Chirosree Bandyopadhyay

Dipanjan Dutta

Bala Chandran

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SD BC. Performed the experiments: SD CW CB DD. Analyzed the data: SD BC. Wrote the paper: SD BC.

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Exosomes
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Breast cancer
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Autophagic cell death
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Phosphorylation
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Epithelial cells
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Cancer treatment
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Cell growth
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Fibroblasts
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