Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

Rotonya M. Carr; Giselle Peralta; Xiaoyan Yin; Rexford S. Ahima

doi:10.1371/journal.pone.0097118

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Open Access

Peer-reviewed

Research Article

Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

Rotonya M. Carr ,

* E-mail: Rotonya.Carr@uphs.upenn.edu

Affiliation University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Gastroenterology Division, Philadelphia, Pennsylvania, United States of America
⨯
Giselle Peralta,

Affiliation University of Pennsylvania, Perelman School of Medicine, Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States of America
⨯
Xiaoyan Yin,

Affiliation University of Pennsylvania, Perelman School of Medicine, Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States of America
⨯
Rexford S. Ahima

Affiliation University of Pennsylvania, Perelman School of Medicine, Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States of America
⨯

Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

Rotonya M. Carr,
Giselle Peralta,
Xiaoyan Yin,
Rexford S. Ahima

Published: May 15, 2014
https://doi.org/10.1371/journal.pone.0097118

About the Authors

Rotonya M. Carr

* E-mail: Rotonya.Carr@uphs.upenn.edu

Affiliation University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Gastroenterology Division, Philadelphia, Pennsylvania, United States of America

Giselle Peralta

Affiliation University of Pennsylvania, Perelman School of Medicine, Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States of America

Xiaoyan Yin

Affiliation University of Pennsylvania, Perelman School of Medicine, Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States of America

Rexford S. Ahima

Affiliation University of Pennsylvania, Perelman School of Medicine, Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMC RSA. Performed the experiments: RMC GP XY. Analyzed the data: RMC GP. Contributed reagents/materials/analysis tools: RMC RSA. Wrote the paper: RMC RSA. Manuscript editing: GP.

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Lipids
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Steatosis
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Alcohol consumption
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Diet
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Lipid metabolism
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Ethanol
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Fatty liver
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Homeostasis
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