About the Authors

Zhipeng Xu

Contributed equally to this work with: Zhipeng Xu, Yuanlin Dong

Affiliation Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts

Yuanlin Dong

Contributed equally to this work with: Zhipeng Xu, Yuanlin Dong

Affiliation Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts

Hui Wang

Affiliations Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, Department of Anesthesia, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China

Deborah J. Culley

Affiliation Department of Anesthesia, Brigham & Women’s Hospital and Harvard Medical School, Boston, Massachusetts

Edward R. Marcantonio

Affiliation Divisions of General Medicine and Primary Care and Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts

Gregory Crosby

Affiliation Department of Anesthesia, Brigham & Women’s Hospital and Harvard Medical School, Boston, Massachusetts

Rudolph E. Tanzi

Affiliation Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts

Yiying Zhang

Affiliation Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts

Zhongcong Xie

zxie@mgh.harvard.edu

Affiliation Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts

Competing Interests

Author, Zhongcong Xie, currently serves as an Academic Editor for this journal. However, this does not alter the author's adherence to PLOS ONE Editorial policies and criteria.

Author Contributions

Conceived and designed the experiments: Z. Xie GC DC EM RT YZ. Performed the experiments: Z. Xu YD HW YZ. Analyzed the data: Z. Xie Z. Xu YD YZ. Contributed reagents/materials/analysis tools: RT GC. Contributed to the writing of the manuscript: Z. Xie RT EM.