About the Authors

Nancy Cheng

Affiliation Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

Melissa A. Porter

Affiliation Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

Lloyd W. Frick

Affiliation DMPK Advisors, Chapel Hill, North Carolina, United States of America

Yvonne Nguyen

Affiliation Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

Jennifer D. Hayden

Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Ellen F. Young

Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Miriam S. Braunstein

Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Emily A. Hull-Ryde

Affiliation Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

William P. Janzen

bjanzen@email.unc.edu

Affiliations Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cancer Genetics Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Competing Interests

Dr. Frick is employed by DMPK Advisors. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: NC MP EH-R WJ MB. Performed the experiments: NC MP YN JH. Analyzed the data: NC LF. Contributed reagents/materials/analysis tools: NC EY JH. Wrote the paper: NC LF MB EH-R WJ.