About the Authors

Halesha D. Basavarajappa

Contributed equally to this work with: Halesha D. Basavarajappa, Bit Lee

Affiliations Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Bit Lee

Contributed equally to this work with: Halesha D. Basavarajappa, Bit Lee

Affiliation College of Pharmacy, Gachon University, Incheon, South Korea

Xiang Fei

Affiliation College of Pharmacy, Gachon University, Incheon, South Korea

Daesung Lim

Affiliation College of Pharmacy, Gachon University, Incheon, South Korea

Breedge Callaghan

Affiliation Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Julie A. Mund

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States Of America

Jamie Case

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States Of America

Gangaraju Rajashekhar

Affiliations Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Seung-Yong Seo

syseo@gachon.ac.kr (S-YS); tcorson@iupui.edu (TWC)

These authors also contributed equally to this work.

Affiliation College of Pharmacy, Gachon University, Incheon, South Korea

Timothy W. Corson

syseo@gachon.ac.kr (S-YS); tcorson@iupui.edu (TWC)

These authors also contributed equally to this work.

Affiliations Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States Of America, Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Competing Interests

HDB, BL, XF, S-YS, and TWC are named on a patent application disclosing the synthesis and antiangiogenic applications of the molecule described in this manuscript. HDB was supported by a scholarship from Kemin Health. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HDB BL XF GR S-YS TWC. Performed the experiments: HDB BL XF DL BC JAM JC GR S-YS TWC. Analyzed the data: HDB JAM GR S-YS TWC. Wrote the paper: HDB BL XF DL BC JAM JC GR S-YS TWC.