About the Authors

Kaoru Aida

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Sei Saitoh

Affiliation Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Yoriko Nishida

Affiliation Department of Nursing, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Sadanori Yokota

Affiliation Section of Functional Morphology, Faculty of Pharmaceutical Sciences, Nagasaki International University, Saseho, Nagasaki, Japan

Shinichi Ohno

Affiliation Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Xiayang Mao

Affiliation Department of Computer Science, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Daiichiro Akiyama

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Shoichiro Tanaka

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Takuya Awata

Affiliation Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Moroyama, Saitama, Japan

Akira Shimada

Affiliation Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan

Youichi Oikawa

Affiliation Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan

Hiroki Shimura

Affiliation Department of Laboratory Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan

Fumihiko Furuya

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Soichi Takizawa

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Masashi Ichijo

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Sayaka Ichijo

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Jun Itakura

Affiliation Department of Surgery I, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Hideki Fujii

Affiliation Department of Surgery I, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Akinori Hashiguchi

Affiliation Department of Pathology, Keio University School of Medicine, Tokyo, Japan

Shin Takasawa

Affiliation Department of Biochemistry, Nara Medical University, Kashihara, Wakayama, Japan

Toyoshi Endo

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Tetsuro Kobayashi

tetsurou@yamanashi.ac.jp

Affiliation Department of Internal Medicine III, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KA SS YN SO HS S. Tanaka TK. Performed the experiments: KA SS YN SY SO XM DA AH S. Takizawa TE TK. Analyzed the data: KA SS YN SY SO XM DA S. Tanaka HS FF MI SI JI HF AH S. Takasawa TE TK. Contributed reagents/materials/analysis tools: TA AS YO Shin Takasawa. Wrote the paper: KA SS YN TK. Editing: SO TK. Critical comments, review and revision: SY HS TA AS YO JI HF.