About the Authors

Patrick Paulus

patrick.paulus@kgu.de

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany

Katrin Rupprecht

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany

Patrick Baer

Affiliation Department of Internal Medicine III, Division of Nephrology, Goethe-University Hospital, Frankfurt am Main, Germany

Nicholas Obermüller

Affiliation Department of Internal Medicine III, Division of Nephrology, Goethe-University Hospital, Frankfurt am Main, Germany

Daniela Penzkofer

Affiliation Institute of Cardiovascular Regeneration, Goethe-University, Frankfurt am Main, Germany

Christin Reissig

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany

Bertram Scheller

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany

Johannes Holfeld

Affiliation Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria

Kai Zacharowski

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany

Stefanie Dimmeler

Affiliation Institute of Cardiovascular Regeneration, Goethe-University, Frankfurt am Main, Germany

Joelle Schlammes

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany

Anja Urbschat

Affiliation Faculty of Medicine, Philipps-University Marburg, Marburg, Germany

Competing Interests

The authors would like to state that besides the present funding the authors have no personal or financial competing interests to declare. The fact that a Bayer AG has sponsored the study does not alter their adherence to PLOS ONE policies on sharing data and materials. There are no restrictions on sharing of data and/or materials of the present study.

Author Contributions

Conceived and designed the experiments: PP AU. Performed the experiments: PP KR PB DP CR BS JH JS AU. Analyzed the data: PP KR NO BS KZ AU. Contributed reagents/materials/analysis tools: KZ SD. Wrote the paper: PP AU KZ SD JH PB NO. Designed the automatized algorithm used in analysis: BS.