About the Authors

Getnet Yimer

Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Marcus Gry

Affiliation Former AstraZeneca R&D, Global Safety Assessment, Molecular Toxicology, Södertälje, Sweden

Wondwossen Amogne

Affiliations Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia, Department of Medicine, Division of Infectious Diseases, Karolinska Institute at Karolinska University Hospital Huddinge I:73, Stockholm, Sweden

Eyasu Makonnen

Affiliation Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Abiy Habtewold

Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Zelalem Petros

Affiliation Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Getachew Aderaye

Affiliation Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Ina Schuppe-Koistinen

Affiliation AstraZeneca Innovative Medicines Personalised Healthcare & Biomarkers, Science for Life Laboratory, Solna, Sweden

Lars Lindquist

Affiliation Department of Medicine, Division of Infectious Diseases, Karolinska Institute at Karolinska University Hospital Huddinge I:73, Stockholm, Sweden

Eleni Aklillu

Eleni.Aklillu@ki.se

Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden

Competing Interests

The authors have read the journal's policy and have the following conflicts. IS-K is an employee of AstraZeneca Innovative Medicines Personalised Healthcare & Biomarkers, Science for Life Laboratory, which had no influence in the conception, design or analysis of this work, and no role in manuscript preparation or publication. MG is an employee of Former AstraZeneca R&D, Global Safety Assessment, Molecular Toxicology, Södertälje, Sweden, which had no influence in the conception, design or analysis of this work, and no role in manuscript preparation or publication. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EA GY WA EM AH GA LL IS-K MG. Performed the experiments: EA GY AH WA ZP. Analyzed the data: EA GY MG IS-K ZP. Contributed reagents/materials/analysis tools: EA. Wrote the paper: EA GA. Review and critique: GY EM LL IS-K ZP.