About the Authors

Julien Burlaud-Gaillard

Affiliation Plate-Forme RIO des Microscopies, PPF ASB, Université François Rabelais and CHRU de Tours, Tours, France

Caroline Sellin

Affiliation Département Bioprocess, Upstream Platform, Sanofi Pasteur, Marcy l'Etoile, France

Sonia Georgeault

Affiliation Plate-Forme RIO des Microscopies, PPF ASB, Université François Rabelais and CHRU de Tours, Tours, France

Rustem Uzbekov

Affiliation Plate-Forme RIO des Microscopies, PPF ASB, Université François Rabelais and CHRU de Tours, Tours, France

Claude Lebos

Affiliation Plate-Forme RIO des Microscopies, PPF ASB, Université François Rabelais and CHRU de Tours, Tours, France

Jean-Marc Guillaume

Affiliation Département Bioprocess, Upstream Platform, Sanofi Pasteur, Marcy l'Etoile, France

Philippe Roingeard

roingeard@med.univ-tours.fr

Affiliations Plate-Forme RIO des Microscopies, PPF ASB, Université François Rabelais and CHRU de Tours, Tours, France, INSERM U966, Université François Rabelais and CHRU de Tours, Tours, France

Competing Interests

CS and JMG are employed by Sanofi Pasteur. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JBG CS JMG PR. Performed the experiments: JBG CS SG RU CL. Analyzed the data: JBG CS JMG PR. Contributed reagents/materials/analysis tools: CS JMG. Wrote the paper: JBG PR.