Model-Based Analysis of Costs and Outcomes of Non-Invasive Prenatal Testing for Down’s Syndrome Using Cell Free Fetal DNA in the UK National Health Service

Stephen Morris; Saffron Karlsen; Nancy Chung; Melissa Hill; Lyn S. Chitty

doi:10.1371/journal.pone.0093559

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Open Access

Peer-reviewed

Research Article

Model-Based Analysis of Costs and Outcomes of Non-Invasive Prenatal Testing for Down’s Syndrome Using Cell Free Fetal DNA in the UK National Health Service

Stephen Morris ,

* E-mail: steve.morris@ucl.ac.uk

Affiliation Department of Applied Health Research, University College London, London, United Kingdom
⨯
Saffron Karlsen,

Affiliation Department of Applied Health Research, University College London, London, United Kingdom
⨯
Nancy Chung,

Affiliation NHS Fetal Anomaly Screening Programme, University of Exeter, Exeter, United Kingdom
⨯
Melissa Hill,

Affiliations Clinical and Molecular Genetics Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, United Kingdom
⨯
Lyn S. Chitty

Affiliations Clinical and Molecular Genetics Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, United Kingdom
⨯

Model-Based Analysis of Costs and Outcomes of Non-Invasive Prenatal Testing for Down’s Syndrome Using Cell Free Fetal DNA in the UK National Health Service

Stephen Morris,
Saffron Karlsen,
Nancy Chung,
Melissa Hill,
Lyn S. Chitty

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0093559

About the Authors

Stephen Morris

* E-mail: steve.morris@ucl.ac.uk

Affiliation Department of Applied Health Research, University College London, London, United Kingdom

Saffron Karlsen

Affiliation Department of Applied Health Research, University College London, London, United Kingdom

Nancy Chung

Affiliation NHS Fetal Anomaly Screening Programme, University of Exeter, Exeter, United Kingdom

Melissa Hill

Affiliations Clinical and Molecular Genetics Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, United Kingdom

Lyn S. Chitty

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM LSC. Performed the experiments: NC SK SM. Analyzed the data: NC SK SM. Contributed reagents/materials/analysis tools: NC MH LSC. Wrote the paper: SM SK NC MH LSC.

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Pregnancy
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Miscarriage
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Chorionic villus sampling
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Down syndrome
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Medical risk factors
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Surgical and invasive medical procedures
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Birth
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Prenatal diagnosis
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