About the Authors
- Hiroshi Saga
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* E-mail: saga@ono.co.jp
Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Akira Ohhata
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Affiliation Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd., Shimamoto, Mishima, Osaka, Japan
- Akio Hayashi
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Makoto Katoh
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Tatsuo Maeda
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Hirotaka Mizuno
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Yuka Takada
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Yuka Komichi
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Hiroto Ota
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Naoya Matsumura
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Affiliation Discovery Technology Laboratories, ONO Pharmaceutical Co., Ltd., Shimamoto, Mishima, Osaka, Japan
- Masami Shibaya
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Affiliation Safety Research Laboratories, ONO Phamaceutical Co., Ltd., Sakai, Fukui, Japan
- Tetsuya Sugiyama
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Shinji Nakade
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
- Katsuya Kishikawa
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Affiliation Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan
Competing Interests
All authors are employees of Ono Pharmaceutical Co. Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: HS TS SN KK. Performed the experiments: HS AO AH MK TM HM YT YK HO NM MS. Analyzed the data: HS AH MK TM YT YK NM MS. Contributed reagents/materials/analysis tools: HS AO MK TM TS. Wrote the paper: HS AH MK TM KK.