The Origin of Novel Avian Influenza A (H7N9) and Mutation Dynamics for Its Human-To-Human Transmissible Capacity

Jin Peng; Hao Yang; Hua Jiang; Yi-xiao Lin; Charles Damien Lu; Ya-wei Xu; Jun Zeng

doi:10.1371/journal.pone.0093094

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Peer-reviewed

Research Article

The Origin of Novel Avian Influenza A (H7N9) and Mutation Dynamics for Its Human-To-Human Transmissible Capacity

Jin Peng ,

Contributed equally to this work with: Jin Peng, Hao Yang, Hua Jiang

Affiliation Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Hao Yang ,

Contributed equally to this work with: Jin Peng, Hao Yang, Hua Jiang

Affiliation Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Hua Jiang ,

Contributed equally to this work with: Jin Peng, Hao Yang, Hua Jiang

* E-mail: cdjianghua@gmail.com (HJ); zengjun@medmail.com.cn (JZ)

Affiliations Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China, Emergency Medicine Center, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Yi-xiao Lin,

Affiliation Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Charles Damien Lu,

Affiliation Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Ya-wei Xu,

Affiliation Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Jun Zeng

* E-mail: cdjianghua@gmail.com (HJ); zengjun@medmail.com.cn (JZ)

Affiliations Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China, Emergency Medicine Center, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯

The Origin of Novel Avian Influenza A (H7N9) and Mutation Dynamics for Its Human-To-Human Transmissible Capacity

Jin Peng,
Hao Yang,
Hua Jiang,
Yi-xiao Lin,
Charles Damien Lu,
Ya-wei Xu,
Jun Zeng

Published: March 26, 2014
https://doi.org/10.1371/journal.pone.0093094

About the Authors

Jin Peng

Contributed equally to this work with: Jin Peng, Hao Yang, Hua Jiang

Affiliation Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China

Hao Yang

Contributed equally to this work with: Jin Peng, Hao Yang, Hua Jiang

Hua Jiang

Contributed equally to this work with: Jin Peng, Hao Yang, Hua Jiang

* E-mail: cdjianghua@gmail.com (HJ); zengjun@medmail.com.cn (JZ)

Affiliations Department of Computational Mathematics and Bio-Statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Institute for Emergency and Disaster Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China, Emergency Medicine Center, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China

Yi-xiao Lin

Charles Damien Lu

Ya-wei Xu

Jun Zeng

* E-mail: cdjianghua@gmail.com (HJ); zengjun@medmail.com.cn (JZ)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP HJ JZ. Performed the experiments: JP HY YXL YWX. Analyzed the data: JP HY HJ CDL JZ. Wrote the paper: HJ CDL. Reviewed/commented on the manuscript: JP HY HJ YXL CDL YWX JZ.

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H7N9
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Influenza viruses
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Microbial mutation
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Bird genetics
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Protein sequencing
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Avian influenza
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Animal migration
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