About the Authors

David Britton

david.britton@proteomics.com

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Yoh Zen

Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom

Alberto Quaglia

Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom

Stefan Selzer

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Vikram Mitra

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Christopher Lößner

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Stephan Jung

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Gitte Böhm

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Peter Schmid

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Petra Prefot

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Claudia Hoehle

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Sasa Koncarevic

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Julia Gee

Affiliation Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom

Robert Nicholson

Affiliation Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom

Malcolm Ward

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Leandro Castellano

Affiliation Faculty of Medicine, Department of Surgery & Cancer, Imperial College, London, United Kingdom

Justin Stebbing

Affiliation Faculty of Medicine, Department of Surgery & Cancer, Imperial College, London, United Kingdom

Hans Dieter Zucht

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Debashis Sarker

Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom

Nigel Heaton

Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom

Ian Pike

Affiliation Proteome Sciences plc, Cobham, United Kingdom

Competing Interests

We have the following interests. This study was partly funded by Proteome Sciences plc, the employer of David Britton, Stefan Selzer, Vikram Mitra, Christopher Lößner, Stephan Jung, Gitte Böhm, Peter Schmid, Petra Prefot, Claudia Hoehle, Sasa Koncarevic, Malcolm Ward, Hans Dieter Zucht and Ian Pike. All employees of Proteome Sciences plc (except newly recruited Vikram Mitra) hold stock or stock options in Proteome Sciences plc. Proteome Sciences also produce the TMT reagents used in this study and these reagents are now licensed for distribution by Thermo Fisher Scientific. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: DB IP YZ AQ NH MW. Performed the experiments: DB YZ CL SJ GB PS PP CH SK LC. Analyzed the data: DB YZ SS CL VM SK HDZ IP. Contributed reagents/materials/analysis tools: YZ AQ JG RN LC JS DS NH. Wrote the paper: DB YZ AQ SS CL SJ GB LC JS NH IP.