About the Authors
- David Britton
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* E-mail: david.britton@proteomics.com
Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Yoh Zen
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Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom
- Alberto Quaglia
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Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom
- Stefan Selzer
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Vikram Mitra
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Christopher Lößner
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Stephan Jung
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Gitte Böhm
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Peter Schmid
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Petra Prefot
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Claudia Hoehle
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Sasa Koncarevic
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Julia Gee
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Affiliation Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom
- Robert Nicholson
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Affiliation Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom
- Malcolm Ward
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Leandro Castellano
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Affiliation Faculty of Medicine, Department of Surgery & Cancer, Imperial College, London, United Kingdom
- Justin Stebbing
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Affiliation Faculty of Medicine, Department of Surgery & Cancer, Imperial College, London, United Kingdom
- Hans Dieter Zucht
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
- Debashis Sarker
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Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom
- Nigel Heaton
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Affiliation Institute of Liver Studies, King's College Hospital, London, United Kingdom
- Ian Pike
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Affiliation Proteome Sciences plc, Cobham, United Kingdom
Competing Interests
We have the following interests. This study was partly funded by Proteome Sciences plc, the employer of David Britton, Stefan Selzer, Vikram Mitra, Christopher Lößner, Stephan Jung, Gitte Böhm, Peter Schmid, Petra Prefot, Claudia Hoehle, Sasa Koncarevic, Malcolm Ward, Hans Dieter Zucht and Ian Pike. All employees of Proteome Sciences plc (except newly recruited Vikram Mitra) hold stock or stock options in Proteome Sciences plc. Proteome Sciences also produce the TMT reagents used in this study and these reagents are now licensed for distribution by Thermo Fisher Scientific. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: DB IP YZ AQ NH MW. Performed the experiments: DB YZ CL SJ GB PS PP CH SK LC. Analyzed the data: DB YZ SS CL VM SK HDZ IP. Contributed reagents/materials/analysis tools: YZ AQ JG RN LC JS DS NH. Wrote the paper: DB YZ AQ SS CL SJ GB LC JS NH IP.