About the Authors

Erica B. Schleifman

Contributed equally to this work with: Erica B. Schleifman, Rachel Tam

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Rachel Tam

Contributed equally to this work with: Erica B. Schleifman, Rachel Tam

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Rajesh Patel

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Alison Tsan

Affiliation Chemistry and Innovation Technology, Pleasanton, California, United States of America

Teiko Sumiyoshi

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Ling Fu

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Rupal Desai

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Nancy Schoenbrunner

Affiliation Chemistry and Innovation Technology, Pleasanton, California, United States of America

Thomas W. Myers

Affiliation Program in Core Research, Roche Molecular Systems Inc., Pleasanton, California, United States of America

Keith Bauer

Affiliation Program in Core Research, Roche Molecular Systems Inc., Pleasanton, California, United States of America

Edward Smith

Affiliation Program in Core Research, Roche Molecular Systems Inc., Pleasanton, California, United States of America

Rajiv Raja

raja.rajiv@gene.com

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: All studies were funded by Genentech, Inc. Erica Schleifman, Rachel Tam, Rajesh Patel, Teiko Sumiyoshi, Ling Fu, Rupal Desai, and Rajiv Raja are or were employed by Genentech, and Alison Tsan, Nancy Schoenbrunner, Thomas W. Myers, Keith Bauer, and Edward Smith are or were employed by Roche Molecular Systems Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RR RP. Performed the experiments: RT E. Schleifman RP RD. Analyzed the data: RP E. Schleifman RT TS. Contributed reagents/materials/analysis tools: RP AT RT RD LF NS TM KB E. Smith RR. Wrote the paper: E. Schleifman RT RP AT NS TM KB E. Smith RR.