About the Authors

John C. Morris

morri2j7@ucmail.uc.edu (JCM); berzofsj@mail.nih.gov (JAB)

Current address: Division of Hematology-Oncology, Department of Medicine, University of Cincinnati, Vontz Center for Molecular Studies, ML0562, Cincinnati, Ohio, United States of America

Affiliation Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Antoinette R. Tan

Affiliation Department of Medicine, The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America

Thomas E. Olencki

Affiliation Department of Medicine, The Ohio State University, Columbus, Ohio, United States of America

Geoffrey I. Shapiro

Affiliation Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Bruce J. Dezube

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Michael Reiss

Affiliation Department of Medicine, The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America

Frank J. Hsu

Affiliation Genzyme Corporation, Cambridge, Massachusetts, United States of America

Jay A. Berzofsky

morri2j7@ucmail.uc.edu (JCM); berzofsj@mail.nih.gov (JAB)

Affiliation Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Donald P. Lawrence

Affiliation Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have the following interests: FJ Hsu was an employee of Genzyme Corporation. JA Berzofsky received research support from Genzyme Corporation, and M Reiss was a consultant on Advisory Boards for Genzyme Corporation. This work was partly supported by Genzyme Corporation who also provided the investigational agent GC1008. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JCM FJH ART MR JAB. Performed the experiments: JCM ART TEO GIS BJD DPL. Analyzed the data: JCM FJH JAB. Contributed reagents/materials/analysis tools: JCM ART TEO GIS BJD DPL FJH JAB MR. Wrote the paper: JCM FJH JAB. Review, editing and approval of manuscript: JCM ART TEO GIS BJD DPL FJH JAB MR.