About the Authors

Bianca C. Bernardo

bianca.bernardo@bakeridi.edu.au (BCB); julie.mcmullen@bakeridi.edu.au (JRM)

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Xiao-Ming Gao

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Yow Keat Tham

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Helen Kiriazis

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Catherine E. Winbanks

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Jenny Y. Y. Ooi

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Esther J. H. Boey

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Susanna Obad

Affiliation Santaris Pharma, Horsholm, Denmark

Sakari Kauppinen

Affiliation Department of Haematology, Aalborg University Hospital, Copenhagen, Denmark

Paul Gregorevic

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Xiao-Jun Du

Affiliation Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

Ruby C. Y. Lin

Affiliation Ramaciotti Centre for Genomics, School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia

Julie R. McMullen

bianca.bernardo@bakeridi.edu.au (BCB); julie.mcmullen@bakeridi.edu.au (JRM)

Affiliations Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia, Departments of Medicine Monash University, Clayton, Victoria, Australia, Departments of Physiology, Monash University, Clayton, Victoria, Australia

Competing Interests

S.O. is an employee of Santaris Pharma A/S, a clinical stage biopharmaceutical company that develops RNA-based therapeutics. S.K. is a former employee of Santaris Pharma A/S and is now Professor at the Department of Haematology, Aalborg University Hospital. Depending on the field of use, LNA oligonucleotides can be obtained from Santaris Pharma A/S or Exiqon. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BCB SO SK RCYL JRM. Performed the experiments: BCB XMG YKT HK CEW JYYO EJHB XJD JRM. Analyzed the data: BCB CEW JYYO YKT JRM. Contributed reagents/materials/analysis tools: SO SK PG. Wrote the paper: BCB JRM.