About the Authors

Nicolas Bertheleme

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

Annette Strege

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

Sorrel E. Bunting

Current address: King's College London, London, United Kingdom

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

Simon J. Dowell

Affiliation Department of Molecular Discovery Research, GlaxoSmithKline, Hertfordshire, United Kingdom

Bernadette Byrne

b.byrne@imperial.ac.uk

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

Competing Interests

The authors have the following interests: Dr. Simon J. Dowell is employed by GSK. This study was funded by GSK. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NB BB. Performed the experiments: NB AS SEB. Analyzed the data: NB AS BB. Contributed reagents/materials/analysis tools: SJD. Wrote the paper: NB SJD BB.