Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

Jung-Yi Lisa Chan; Kuo-Hsien Wang; Chia-Lang Fang; Wei-Yu Chen

doi:10.1371/journal.pone.0089467

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Peer-reviewed

Research Article

Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

Jung-Yi Lisa Chan,

Affiliation Department of Dermatology, Cathay General Hospital, Taipei, Taiwan
⨯
Kuo-Hsien Wang,

Affiliations Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan, Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
⨯
Chia-Lang Fang,

Affiliations Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
⨯
Wei-Yu Chen

* E-mail: 1047@tmu.edu.tw

Affiliations Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
⨯

Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

Jung-Yi Lisa Chan,
Kuo-Hsien Wang,
Chia-Lang Fang,
Wei-Yu Chen

Published: February 18, 2014
https://doi.org/10.1371/journal.pone.0089467

About the Authors

Jung-Yi Lisa Chan

Affiliation Department of Dermatology, Cathay General Hospital, Taipei, Taiwan

Kuo-Hsien Wang

Affiliations Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan, Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

Chia-Lang Fang

Affiliations Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Wei-Yu Chen

* E-mail: 1047@tmu.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WYC JYC KHW. Performed the experiments: WYC JYC. Analyzed the data: JYC KHW CLF WYC. Contributed reagents/materials/analysis tools: WYC JYC. Wrote the paper: WYC JYC.

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Stromal cells
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Keratinocytes
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Lesions
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Epidermis
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Histology
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Pathogenesis
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Face
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Fibroblasts
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