Effect of Diet on Expression of Genes Involved in Lipid Metabolism, Oxidative Stress, and Inflammation in Mouse Liver–Insights into Mechanisms of Hepatic Steatosis

Helen J. Renaud; Julia Y. Cui; Hong Lu; Curtis D. Klaassen

doi:10.1371/journal.pone.0088584

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Open Access

Peer-reviewed

Research Article

Effect of Diet on Expression of Genes Involved in Lipid Metabolism, Oxidative Stress, and Inflammation in Mouse Liver–Insights into Mechanisms of Hepatic Steatosis

Helen J. Renaud,

Affiliation Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, United States of America
⨯
Julia Y. Cui,

Affiliation Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, United States of America
⨯
Hong Lu,

Affiliation Department of Pharmacology, State University of New York, Syracuse, New York, United States of America
⨯
Curtis D. Klaassen

* E-mail: cklaasse@kumc.edu

Affiliation Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, United States of America
⨯

Effect of Diet on Expression of Genes Involved in Lipid Metabolism, Oxidative Stress, and Inflammation in Mouse Liver–Insights into Mechanisms of Hepatic Steatosis

Helen J. Renaud,
Julia Y. Cui,
Hong Lu,
Curtis D. Klaassen

Published: February 14, 2014
https://doi.org/10.1371/journal.pone.0088584

About the Authors

Helen J. Renaud

Affiliation Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, United States of America

Julia Y. Cui

Affiliation Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, United States of America

Hong Lu

Affiliation Department of Pharmacology, State University of New York, Syracuse, New York, United States of America

Curtis D. Klaassen

* E-mail: cklaasse@kumc.edu

Affiliation Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL CDK. Performed the experiments: HL JYC. Analyzed the data: HJR. Contributed reagents/materials/analysis tools: CDK. Wrote the paper: HJR.

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Diet
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Gene expression
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Cholesterol
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Fatty liver
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Diet and type 2 diabetes
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Fatty acids
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Glutathione
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Hierarchical clustering
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