Human FXR Regulates SHP Expression through Direct Binding to an LRH-1 Binding Site, Independent of an IR-1 and LRH-1

Martijn O. Hoeke; Janette Heegsma; Mark Hoekstra; Han Moshage; Klaas Nico Faber

doi:10.1371/journal.pone.0088011

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Open Access

Peer-reviewed

Research Article

Human FXR Regulates SHP Expression through Direct Binding to an LRH-1 Binding Site, Independent of an IR-1 and LRH-1

Martijn O. Hoeke,

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands
⨯
Janette Heegsma,

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands
⨯
Mark Hoekstra,

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands
⨯
Han Moshage,

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands
⨯
Klaas Nico Faber

* E-mail: k.n.faber@ umcg.nl

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands
⨯

Human FXR Regulates SHP Expression through Direct Binding to an LRH-1 Binding Site, Independent of an IR-1 and LRH-1

Martijn O. Hoeke,
Janette Heegsma,
Mark Hoekstra,
Han Moshage,
Klaas Nico Faber

Published: February 3, 2014
https://doi.org/10.1371/journal.pone.0088011

About the Authors

Martijn O. Hoeke

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands

Janette Heegsma

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands

Mark Hoekstra

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands

Han Moshage

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands

Klaas Nico Faber

* E-mail: k.n.faber@ umcg.nl

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MOH JH MH HM KNF. Performed the experiments: MOH JH MH. Analyzed the data: MOH JH MH KNF. Wrote the paper: MOH MH HM KNF.

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Luciferase
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