About the Authors

Yan Shen

Affiliation Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan

Natsumi Honma

Affiliation Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan

Katsuya Kobayashi

Affiliation Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan

Liu Nan Jia

Affiliation School of Pharmacy, Nihon University, Chiba, Japan

Takashi Hosono

hosono.takashi@nihon-u.ac.jp

Affiliation Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan

Kazutoshi Shindo

Affiliation Department of Food and Nutrition, Japan Women’s University, Tokyo, Japan

Toyohiko Ariga

Affiliation Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan

Taiichiro Seki

Affiliation Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan

Competing Interests

The Cinnamon (Cinnamomum zeylanicum) used in this study was a gift from House Foods Corporation (Tokyo). This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. The authors have declared that no other competing interests exist.

Author Contributions

Conceived and designed the experiments: YS. Performed the experiments: YS NH KK. Analyzed the data: YS NH KK. Wrote the paper: YS. Contribution to the discussion section of the manuscript: LNJ KS TH TS. Conducted some of the research: TH. Reviewed/edited the manuscript: TA TS.