The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis

Hidekata Yasuoka; Yukie Yamaguchi; Carol A. Feghali-Bostwick

doi:10.1371/journal.pone.0087754

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Peer-reviewed

Research Article

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis

Hidekata Yasuoka,

Affiliations Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
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Yukie Yamaguchi,

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Carol A. Feghali-Bostwick

* E-mail: feghalib@musc.edu

Affiliations Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis

Hidekata Yasuoka,
Yukie Yamaguchi,
Carol A. Feghali-Bostwick

Published: February 13, 2014
https://doi.org/10.1371/journal.pone.0087754

About the Authors

Hidekata Yasuoka

Affiliations Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Yukie Yamaguchi

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Carol A. Feghali-Bostwick

* E-mail: feghalib@musc.edu

Affiliations Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

Competing Interests

Carol Feghali-Bostwick is a PLOS ONE academic editor. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data materials.

Author Contributions

Conceived and designed the experiments: HY YY CFB. Performed the experiments: HY YY. Analyzed the data: HY YY CFB. Contributed reagents/materials/analysis tools: CFB. Wrote the paper: HY CFB.

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Fibroblasts
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Fibrosis
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Skin
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Immunoblotting
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Lungs
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MAPK signaling cascades
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Skin tissue
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Tyrosine kinases
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