About the Authors

Andrea Degasperi

andrea.degasperi@ucd.ie

Affiliation Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland

Marc R. Birtwistle

Affiliation Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Natalia Volinsky

Affiliation Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland

Jens Rauch

Affiliation Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland

Walter Kolch

Affiliations Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Republic of Ireland, School of Medicine and Medical Science, University College Dublin, Dublin, Republic of Ireland

Boris N. Kholodenko

Affiliations Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Republic of Ireland, School of Medicine and Medical Science, University College Dublin, Dublin, Republic of Ireland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AD NV JR. Performed the experiments: AD NV JR. Analyzed the data: AD MB BK NV JR. Contributed reagents/materials/analysis tools: AD NV JR. Wrote the paper: AD MB NV JR WK BK. Identified key research questions: AD MB BK.