Long-Time Treatment by Low-Dose N-Acetyl-L-Cysteine Enhances Proinflammatory Cytokine Expressions in LPS-Stimulated Macrophages

Tomokazu Ohnishi; Kenjiro Bandow; Kyoko Kakimoto; Joji Kusuyama; Tetsuya Matsuguchi

doi:10.1371/journal.pone.0087229

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Peer-reviewed

Research Article

Long-Time Treatment by Low-Dose N-Acetyl-L-Cysteine Enhances Proinflammatory Cytokine Expressions in LPS-Stimulated Macrophages

Tomokazu Ohnishi,

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Kenjiro Bandow,

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Kyoko Kakimoto,

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Joji Kusuyama,

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Tetsuya Matsuguchi

* E-mail: tmatsugu@dent.kagoshima-u.ac.jp

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯

Long-Time Treatment by Low-Dose N-Acetyl-L-Cysteine Enhances Proinflammatory Cytokine Expressions in LPS-Stimulated Macrophages

Tomokazu Ohnishi,
Kenjiro Bandow,
Kyoko Kakimoto,
Joji Kusuyama,
Tetsuya Matsuguchi

Published: February 4, 2014
https://doi.org/10.1371/journal.pone.0087229

About the Authors

Tomokazu Ohnishi

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Kenjiro Bandow

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Kyoko Kakimoto

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Joji Kusuyama

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Tetsuya Matsuguchi

* E-mail: tmatsugu@dent.kagoshima-u.ac.jp

Affiliation Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TO KB. Performed the experiments: TO KB KK JK TM. Analyzed the data: TO KB KK JK TM. Contributed reagents/materials/analysis tools: TO KB KK JK TM. Wrote the paper: TO TM.

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Cytokine therapy
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Cytokines
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Macrophages
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Transcription factors
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MAPK signaling cascades
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Phosphatases
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Transfection
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Immune response
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