About the Authors

Tomoko Kashiyama

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Katsutoshi Oda

katsutoshi-tky@umin.ac.jp

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Yuji Ikeda

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Yoshinobu Shiose

Affiliation Oncology Research Laboratories, Daiichi Sankyo Co. Ltd., Tokyo, Japan

Yasuhide Hirota

Affiliation Oncology Research Laboratories, Daiichi Sankyo Co. Ltd., Tokyo, Japan

Kanako Inaba

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Chinami Makii

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Reiko Kurikawa

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Aki Miyasaka

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Takahiro Koso

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Tomohiko Fukuda

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Michihiro Tanikawa

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Keiko Shoji

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Kenbun Sone

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Takahide Arimoto

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Osamu Wada-Hiraike

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Kei Kawana

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Shunsuke Nakagawa

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, Teikyo University, Tokyo, Japan

Koichi Matsuda

Affiliation Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Frank McCormick

Affiliation Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

Hiroyuki Aburatani

Affiliation Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan

Tetsu Yano

Affiliation Department of Obstetrics and Gynecology, National Center for Global Health and Medicine, Tokyo, Japan

Yutaka Osuga

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Tomoyuki Fujii

Affiliation Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

Competing Interests

Yoshinobu Shiose and Yasuhide Hirota are employees of Daiichi Sankyo Co. Ltd, which partly supported this work (to K Oda). DS-7423 is in clinical development by Daiichi Sankyo Co. Ltd and was provided by the company for use in this study. There are no other relevant COI related to employment, consultancy, patents, products in development, or marketed products. These COI do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: T Kashiyama KO YS YH KM. Performed the experiments: T Kashiyama YI YS YH KI CM RK. Analyzed the data: T Kashiyama KO YS YH. Contributed reagents/materials/analysis tools: YI AM T Koso T Fukuda MT K Shoji K Sone TA OW-H KK SN KM FM HA TY YO T Fujii. Wrote the paper: T Kashiyama KO.