About the Authors
- Masato Kiyoshi
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Affiliation Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
- Jose M. M. Caaveiro
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Affiliations Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan
- Eri Miura
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Affiliation Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
- Satoru Nagatoishi
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Affiliation Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
- Makoto Nakakido
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Affiliation Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan
- Shinji Soga
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Affiliation Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan
- Hiroki Shirai
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Affiliation Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan
- Shigeki Kawabata
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Affiliation Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan
- Kouhei Tsumoto
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* E-mail: tsumoto@bioeng.t.u-tokyo.ac.jp
Affiliations Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan, Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Competing Interests
SS, HS, and SK are full-time employees of Astellas Pharma Inc. KT serves as a consultant for Astellas Pharma Inc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MK MN SS HS SK KT. Performed the experiments: MK EM MN SS. Analyzed the data: MK JMMC SN SS HS SK KT. Contributed reagents/materials/analysis tools: MK EM MN SS HS SK KT. Wrote the paper: MK JMMC SN HS KT.