About the Authors

Mitsuko Kawano

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Masafumi Nakayama

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Yusuke Aoshima

Affiliations Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan, Department of Materials Processing, Graduate School of Engineering, Tohoku University, Aramakiaza, Aoba-ku, Sendai, Miyagi, Japan

Kyohei Nakamura

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Mizuho Ono

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Tadashi Nishiya

Affiliation Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan

Syou Nakamura

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Yuri Takeda

Affiliations Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan, Graduate School of Dentistry, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Akira Dobashi

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Akiko Takahashi

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Misato Endo

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Akiyo Ito

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Kyosuke Ueda

Affiliation Department of Materials Processing, Graduate School of Engineering, Tohoku University, Aramakiaza, Aoba-ku, Sendai, Miyagi, Japan

Naoki Sato

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Shigehito Higuchi

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Takeru Kondo

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Suguru Hashimoto

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Masamichi Watanabe

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Makoto Watanabe

Affiliation Graduate School of Dentistry, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Tetsu Takahashi

Affiliation Graduate School of Dentistry, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Keiichi Sasaki

Affiliation Graduate School of Dentistry, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Masanori Nakamura

Affiliation Graduate School of Dentistry, Showa University, Shinagawa-ku, Tokyo, Japan

Takehiko Sasazuki

Affiliation Institute for Advanced Study, Kyushu University, Higashi-ku, Fukuoka, Japan

Takayuki Narushima

Affiliation Department of Materials Processing, Graduate School of Engineering, Tohoku University, Aramakiaza, Aoba-ku, Sendai, Miyagi, Japan

Ryuji Suzuki

Affiliation Department of Rheumatology and Clinical Immunology, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Minami-ku, Sagamihara, Kanagawa, Japan

Kouetsu Ogasawara

ogasawara@idac.tohoku.ac.jp

Affiliation Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Competing Interests

KO has licensed intellectual property rights relative to NKG2D for commercial applications (University of California, San Francisco). There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: KO MK. Performed the experiments: MK YA Masamichi Watanabe MO SN AD. Analyzed the data: KO MK M. Nakayama T. Nishiya KN Masamichi Watanabe KS M. Nakamura TS T. Narushima RS MO SN AD AT ME AI KU NS S. Hashimoto YT TT TK S. Higuchi Makoto Watanabe. Contributed reagents/materials/analysis tools: KO MK M. Nakayama YA. Wrote the manuscript: KO, MK, Masafumi Nakayama.