Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser262 and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

Hamid Y. Qureshi; Dong Han; Ryen MacDonald; Hemant K. Paudel

doi:10.1371/journal.pone.0084615

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Peer-reviewed

Research Article

Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser²⁶² and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

Hamid Y. Qureshi ,

Contributed equally to this work with: Hamid Y. Qureshi, Dong Han

Affiliation Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Dong Han ,

Contributed equally to this work with: Hamid Y. Qureshi, Dong Han

Affiliation Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Ryen MacDonald,

Affiliations Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
⨯
Hemant K. Paudel

* E-mail: hemant.paudel@mcgill.ca

Affiliations Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
⨯

Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser²⁶² and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

Hamid Y. Qureshi,
Dong Han,
Ryen MacDonald,
Hemant K. Paudel

Published: December 19, 2013
https://doi.org/10.1371/journal.pone.0084615

About the Authors

Hamid Y. Qureshi

Contributed equally to this work with: Hamid Y. Qureshi, Dong Han

Affiliation Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

Dong Han

Contributed equally to this work with: Hamid Y. Qureshi, Dong Han

Affiliation Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

Ryen MacDonald

Affiliations Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada

Hemant K. Paudel

* E-mail: hemant.paudel@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HQ DH HP. Performed the experiments: HQ DH. Analyzed the data: HQ DH HP RM. Contributed reagents/materials/analysis tools: HP. Wrote the manuscript: HQ DH HP RM.

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Phosphorylation
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Neurons
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Microtubules
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Alzheimer's disease
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Hyperexpression techniques
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Synapses
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Neuronal differentiation
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Hippocampus
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