Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response

Jop H. van Berlo; Bruce J. Aronow; Jeffery D. Molkentin

doi:10.1371/journal.pone.0084591

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Open Access

Peer-reviewed

Research Article

Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response

Jop H. van Berlo,

Affiliation From the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Ohio, United States of America
⨯
Bruce J. Aronow,

Affiliation From the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Ohio, United States of America
⨯
Jeffery D. Molkentin

* E-mail: Jeff.Molkentin@cchmc.org

Affiliations From the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Ohio, United States of America, Howard Hughes Medical Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯

Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response

Jop H. van Berlo,
Bruce J. Aronow,
Jeffery D. Molkentin

Published: December 31, 2013
https://doi.org/10.1371/journal.pone.0084591

About the Authors

Jop H. van Berlo

Affiliation From the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Ohio, United States of America

Bruce J. Aronow

Affiliation From the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Ohio, United States of America

Jeffery D. Molkentin

* E-mail: Jeff.Molkentin@cchmc.org

Affiliations From the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Ohio, United States of America, Howard Hughes Medical Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JvB JDM. Performed the experiments: JvB. Analyzed the data: JvB JDM BJA. Contributed reagents/materials/analysis tools: JDM. Wrote the paper: JDM.

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Heart
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Gene expression
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Gene regulation
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Heart failure
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Cardiac hypertrophy
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Angiogenesis
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Heterozygosity
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