About the Authors
- John C. Vardakis
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Affiliation Institute of Biomedical Engineering and Department of Engineering Science, University of Oxford, Oxford, United Kingdom
- Brett J. Tully
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Affiliation Oxyntix Ltd., Department of Engineering Science, University of Oxford, Oxford, United Kingdom
- Yiannis Ventikos
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* E-mail: y.ventikos@ucl.ac.uk
Affiliation Department of Mechanical Engineering, University College London, Torrington Place, London, United Kingdom
Competing Interests
Dr. Brett Tully is currently employed by Oxyntix Ltd. However, the topic of this paper is completely disconnected to the activities of Oxyntix: the authors’ article involves medical interventions for cerebral disease whereas the company Dr. Tully currently works for is active in the field of energy. The contributions of Dr. Brett Tully to this article were completed outside his company’s interests, and are connected to his previous occupation as a researcher at the University of Oxford. Furthermore, there are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: JCV YV. Performed the experiments: JCV BJT. Analyzed the data: JCV YV. Contributed reagents/materials/analysis tools: JCV BJT YV. Wrote the paper: JCV YV. Developed the framework for the coupling environment for the surgical modelling platform, conducted simulations, reviewed and expanded the results obtained and contributed to the manuscript preparation: JCV. Contributed in the development of the core multicompartmental poroelasticity model and conducted extensive systematic analyses for determining parameters of the model: BJT. Led the research, provided guidance regarding the computational modelling aspects of the platform, reviewed and expanded the results obtained and contributed to the manuscript preparation: YV.