About the Authors

Takeshi Ishikawa

Affiliations Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, Department of Cancer ImmunoCell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan

Satoshi Kokura

s-kokura@koto.kpu-m.ac.jp

Affiliations Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, Department of Cancer ImmunoCell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan

Tatsuji Enoki

Affiliation Center for Cell and Gene Therapy, Takara Bio Inc, Otsu, Japan

Naoyuki Sakamoto

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Tetsuya Okayama

Affiliations Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, Department of Cancer ImmunoCell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan

Mitsuko Ideno

Affiliation Center for Cell and Gene Therapy, Takara Bio Inc, Otsu, Japan

Junichi Mineno

Affiliation Center for Cell and Gene Therapy, Takara Bio Inc, Otsu, Japan

Kazuko Uno

Affiliation Division of Basic Research, Louis Pasteur Center for Medical Research, Kyoto, Japan

Naohisa Yoshida

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kazuhiro Kamada

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kazuhiro Katada

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kazuhiko Uchiyama

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Osamu Handa

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Tomohisa Takagi

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Hideyuki Konishi

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Nobuaki Yagi

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yuji Naito

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yoshito Itoh

Affiliation Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Toshikazu Yoshikawa

Affiliation Department of Cancer ImmunoCell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan

Competing Interests

Takeshi Ishikawa, Satoshi Kokura, Tetsuya Okayama, and Toshikazu Yoshikawa have an affiliation with a donation-funded department from TAKARA BIO Inc. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TI SK TE JM. Performed the experiments: TI SK TE MI TO NS. Analyzed the data: TI SK TE MI. Contributed reagents/materials/analysis tools: TI TE MI KU. Wrote the paper: TI TE. Intellectual input and data analysis support: NY K. Kamada K. Katada KU OH TT HK NY YN YI TY.