About the Authors

Neil Johns

Affiliation Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom

Shinji Hatakeyama

Affiliation Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, Basel, Switzerland

Nathan A. Stephens

Affiliation Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom

Martin Degen

Affiliation Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, Basel, Switzerland

Simone Degen

Affiliation Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, Basel, Switzerland

Wilfried Frieauff

Affiliation Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, Basel, Switzerland

Christian Lambert

Affiliation Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, Basel, Switzerland

James A. Ross

Affiliation Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom

Ronenn Roubenoff

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

David J. Glass

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Carsten Jacobi

Contributed equally to this work with: Carsten Jacobi, Kenneth C. H. Fearon

Affiliation Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, Basel, Switzerland

Kenneth C. H. Fearon

Contributed equally to this work with: Carsten Jacobi, Kenneth C. H. Fearon

k.fearon@ed.ac.uk

Affiliation Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom

Competing Interests

Shinji Hatakeyama, Martin Degen, Simone Degen, Wilfried Frieauff, Christian Lambert, Ronenn Roubenoff, David Glass and Carsten Jacobi are all employees of Novartis. Regarding the employees of Novartis, this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JAR RR DJG CJ KCHF. Performed the experiments: NJ SH NAS MD SD WF CL. Analyzed the data: NJ SH CJ KCHF. Contributed reagents/materials/analysis tools: MD SD WF CL. Wrote the paper: NJ SH NAS JAR RR DJG CJ KCHF. N/A.