About the Authors

Emilio Satoshi Hara

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Mitsuaki Ono

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Takanori Eguchi

Affiliation Department of Radiation Oncology, Division of Molecular and Cellular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Satoshi Kubota

Affiliation Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Hai Thanh Pham

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Wataru Sonoyama

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Shoji Tajima

Affiliation Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Suita, Osaka, Japan

Masaharu Takigawa

Affiliation Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Stuart K. Calderwood

Affiliation Department of Radiation Oncology, Division of Molecular and Cellular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Takuo Kuboki

kuboki@md.okayama-u.ac.jp

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama-ken, Japan

Competing Interests

The authors declare no competing interests. BD laboratory in Kobe provided cell sorting services for this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ESH MO TE WS SK. Performed the experiments: ESH MO HTP. Analyzed the data: ESH MO TE SK WS ST MT SKC TK. Contributed reagents/materials/analysis tools: ESH MO SK ST MT. Wrote the paper: ESH MO TE SK WS SKC TK.