PknE, a Serine/Threonine Protein Kinase of Mycobacterium tuberculosis Initiates Survival Crosstalk That Also Impacts HIV Coinfection

Dinesh Kumar Parandhaman; Luke Elizabeth Hanna; Sujatha Narayanan

doi:10.1371/journal.pone.0083541

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Open Access

Peer-reviewed

Research Article

PknE, a Serine/Threonine Protein Kinase of Mycobacterium tuberculosis Initiates Survival Crosstalk That Also Impacts HIV Coinfection

Dinesh Kumar Parandhaman,

Affiliation Department of Immunology, National Institute for Research in Tuberculosis, Chennai, TamilNadu, India
⨯
Luke Elizabeth Hanna,

Affiliation Department of Clinic Research, HIV division, National Institute for Research in Tuberculosis, Chennai, TamilNadu, India
⨯
Sujatha Narayanan

* E-mail: sujatha.sujatha36@gmail.com

Affiliation Department of Immunology, National Institute for Research in Tuberculosis, Chennai, TamilNadu, India
⨯

PknE, a Serine/Threonine Protein Kinase of Mycobacterium tuberculosis Initiates Survival Crosstalk That Also Impacts HIV Coinfection

Dinesh Kumar Parandhaman,
Luke Elizabeth Hanna,
Sujatha Narayanan

Published: January 8, 2014
https://doi.org/10.1371/journal.pone.0083541

About the Authors

Dinesh Kumar Parandhaman

Affiliation Department of Immunology, National Institute for Research in Tuberculosis, Chennai, TamilNadu, India

Luke Elizabeth Hanna

Affiliation Department of Clinic Research, HIV division, National Institute for Research in Tuberculosis, Chennai, TamilNadu, India

Sujatha Narayanan

* E-mail: sujatha.sujatha36@gmail.com

Affiliation Department of Immunology, National Institute for Research in Tuberculosis, Chennai, TamilNadu, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DKP SN. Performed the experiments: DKP LEH. Analyzed the data: DKP LEHSN. Contributed reagents/materials/analysis tools: SN. Wrote the paper: DKP SN LEH.

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Macrophages
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MAPK signaling cascades
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Mycobacterium tuberculosis
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Co-infections
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Apoptosis
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Cellular crosstalk
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Phosphorylation
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HIV
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