About the Authors

Jifeng Zhang

Affiliation Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Changyong Xue

Affiliation Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Tianqing Zhu

Affiliation Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Anuradha Vivekanandan

Affiliation Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Subramaniam Pennathur

Affiliation Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Zhongmin Alex Ma

Affiliation Diapin Therapeutics Limited Liability Company, Ann Arbor, Michigan, United States of America

Y. Eugene Chen

echunum@umich.edu

Affiliation Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

Competing Interests

Dr. Ma is an employee and Dr. Chen is a major partner in Diapin Therapeutics LLC, a company developing Diapin to treat T2D. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: YEC. Performed the experiments: JZ CX TZ. Analyzed the data: JZ CX TZ. Contributed reagents/materials/analysis tools: AV SP. Wrote the paper: ZAM.