About the Authors

Hong-xia Chen

Contributed equally to this work with: Hong-xia Chen, Zeng-liang Jin

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Zeng-liang Jin

Contributed equally to this work with: Hong-xia Chen, Zeng-liang Jin

Affiliations Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China, Department of Pharmacology, School of Basic Medical Scieneces, Capital Medical University, Beijing, P. R. of China

Li-ming Zhang

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Rui Xue

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Xiao-dan Xu

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Nan Zhao

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Zhi-kun Qiu

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Xian-wang Wang

Affiliations Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China, Department of Anesthesiology, Chinese PLA 309 Hospital, Beijing, P. R. of China

You-zhi Zhang

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Ri-fang Yang

lyf619@aliyun.com (YL); yangrf@yahoo.com (RY)

Affiliation Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Yun-feng Li

lyf619@aliyun.com (YL); yangrf@yahoo.com (RY)

Affiliation Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. of China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HC ZJ YL. Performed the experiments: HC ZJ YZ XX LZ RX NZ ZQ XW. Analyzed the data: HC ZJ RY YL. Contributed reagents/materials/analysis tools: HC ZJ RY YL. Wrote the paper: HC ZJ YL.