Vitamin A Deficiency Impairs Adaptive B and T Cell Responses to a Prototype Monovalent Attenuated Human Rotavirus Vaccine and Virulent Human Rotavirus Challenge in a Gnotobiotic Piglet Model

Kuldeep S. Chattha; Sukumar Kandasamy; Anastasia N. Vlasova; Linda J. Saif

doi:10.1371/journal.pone.0082966

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Peer-reviewed

Research Article

Vitamin A Deficiency Impairs Adaptive B and T Cell Responses to a Prototype Monovalent Attenuated Human Rotavirus Vaccine and Virulent Human Rotavirus Challenge in a Gnotobiotic Piglet Model

Kuldeep S. Chattha ,

* E-mail: saif.2@osu.edu (LJS); chattha.2@osu.edu (KSC)

Affiliation Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, United States of America
⨯
Sukumar Kandasamy,

Affiliation Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, United States of America
⨯
Anastasia N. Vlasova,

Affiliation Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, United States of America
⨯
Linda J. Saif

* E-mail: saif.2@osu.edu (LJS); chattha.2@osu.edu (KSC)

Affiliation Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, United States of America
⨯

Vitamin A Deficiency Impairs Adaptive B and T Cell Responses to a Prototype Monovalent Attenuated Human Rotavirus Vaccine and Virulent Human Rotavirus Challenge in a Gnotobiotic Piglet Model

Kuldeep S. Chattha,
Sukumar Kandasamy,
Anastasia N. Vlasova,
Linda J. Saif

Published: December 2, 2013
https://doi.org/10.1371/journal.pone.0082966

About the Authors

Kuldeep S. Chattha

* E-mail: saif.2@osu.edu (LJS); chattha.2@osu.edu (KSC)

Affiliation Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, United States of America

Sukumar Kandasamy

Anastasia N. Vlasova

Linda J. Saif

* E-mail: saif.2@osu.edu (LJS); chattha.2@osu.edu (KSC)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KSC ANV LJS. Performed the experiments: KSC SK ANV. Analyzed the data: KSC. Contributed reagents/materials/analysis tools: KSC SK ANV LJS. Wrote the manuscript: KSC LJS.

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Vitamin A
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Vaccination and immunization
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Antibodies
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Gastrointestinal tract
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Diarrhea
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Micronutrient deficiencies
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Swine
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Vaccines
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