The Transcriptomic Response of Rat Hepatic Stellate Cells to Endotoxin: Implications for Hepatic Inflammation and Immune Regulation

Stephen A. K. Harvey; Anil Dangi; Ashish Tandon; Chandrashekhar R. Gandhi

doi:10.1371/journal.pone.0082159

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Open Access

Peer-reviewed

Research Article

The Transcriptomic Response of Rat Hepatic Stellate Cells to Endotoxin: Implications for Hepatic Inflammation and Immune Regulation

Stephen A. K. Harvey ,

Contributed equally to this work with: Stephen A. K. Harvey, Anil Dangi

Affiliation Department of Opthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Anil Dangi ,

Contributed equally to this work with: Stephen A. K. Harvey, Anil Dangi

Affiliations Department of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati VA Medical Center, Cincinnati, Ohio, United States of America
⨯
Ashish Tandon,

Affiliation Department of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Chandrashekhar R. Gandhi

* E-mail: gandhicr@ucmail.uc.edu

Affiliations Department of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati VA Medical Center, Cincinnati, Ohio, United States of America, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯

The Transcriptomic Response of Rat Hepatic Stellate Cells to Endotoxin: Implications for Hepatic Inflammation and Immune Regulation

Stephen A. K. Harvey,
Anil Dangi,
Ashish Tandon,
Chandrashekhar R. Gandhi

Published: December 9, 2013
https://doi.org/10.1371/journal.pone.0082159

About the Authors

Stephen A. K. Harvey

Contributed equally to this work with: Stephen A. K. Harvey, Anil Dangi

Affiliation Department of Opthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Anil Dangi

Contributed equally to this work with: Stephen A. K. Harvey, Anil Dangi

Affiliations Department of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati VA Medical Center, Cincinnati, Ohio, United States of America

Ashish Tandon

Affiliation Department of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America

Chandrashekhar R. Gandhi

* E-mail: gandhicr@ucmail.uc.edu

Affiliations Department of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati VA Medical Center, Cincinnati, Ohio, United States of America, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAKH AD AT CRG. Performed the experiments: SAKH AD AT CRG. Analyzed the data: SAKH AD CRG. Contributed reagents/materials/analysis tools: SAKH AD AT CRG. Wrote the manuscript: SAKH AD CRG.

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Inflammation
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Microarrays
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Toll-like receptors
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T cells
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Chemokines
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Gene expression
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Cytokines
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MAPK signaling cascades
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