About the Authors

Yonchu Jenkins

Contributed equally to this work with: Yonchu Jenkins, Tian-Qiang Sun, Vadim Markovtsov

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Tian-Qiang Sun

Contributed equally to this work with: Yonchu Jenkins, Tian-Qiang Sun, Vadim Markovtsov

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Vadim Markovtsov

Contributed equally to this work with: Yonchu Jenkins, Tian-Qiang Sun, Vadim Markovtsov

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Marc Foretz

Affiliations Inserm, U1016, Institut Cochin, Paris, France, CNRS, UMR8104, Paris, France, Université Paris Descartes, Sorbonne Paris cité, Paris, France

Wei Li

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Henry Nguyen

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Yingwu Li

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Alison Pan

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Gerald Uy

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Lisa Gross

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Kristen Baltgalvis

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Stephanie L. Yung

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Tarikere Gururaja

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Taisei Kinoshita

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Alexander Owyang

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Ira J. Smith

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Kelly McCaughey

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Kathy White

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Guillermo Godinez

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Raniel Alcantara

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Carmen Choy

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Hong Ren

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Rachel Basile

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

David J. Sweeny

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Xiang Xu

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Sarkiz D. Issakani

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

David C. Carroll

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Dane A. Goff

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Simon J. Shaw

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Rajinder Singh

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Laszlo G. Boros

Affiliations SiDMAP, LLC, Los Angeles, California, United States of America, Department of Pediatrics, Los Angeles Biomedical Research Institute (LABIOMED) at the Harbor-UCLA Medical Center, Torrance, California, United States of America

Marc-André Laplante

Affiliation Department of Medicine, Faculty of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Québec, Canada

Bruno Marcotte

Affiliation Department of Medicine, Faculty of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Québec, Canada

Rita Kohen

Affiliation Department of Medicine, Faculty of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Québec, Canada

Benoit Viollet

Affiliations Inserm, U1016, Institut Cochin, Paris, France, CNRS, UMR8104, Paris, France, Université Paris Descartes, Sorbonne Paris cité, Paris, France

André Marette

Affiliation Department of Medicine, Faculty of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Québec, Canada

Donald G. Payan

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Todd M. Kinsella

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Yasumichi Hitoshi

yhitoshi@rigel.com

Affiliation Rigel Pharmaceuticals, Inc., South San Francisco, California, United States of America

Competing Interests

YJ, TQS, VM, WL, HN, YL, AP, GU, LG, KB, SLY, TG, TK, AO, IJS, KM, KW, GG, RA, CC, HR, RB, DJS, XX, SDI, DCC, DAG, SJS, RS, DGP, TMK and YH are or have been employees of Rigel Pharmaceuticals, Inc. LGB is an employee of SiDMAP, LLC. The remaining authors declare no competing financial interests. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YJ VM TQS TMK DPG YH. Performed the experiments: YJ VM TQS TMK YH WQL MF BV HN YL AP GU LG KB SLY TG TK AO IJS KM KW GG RA CC HR RB DJS XX SDI DCC DAG SJS RS LGB MAL BM RK AM. Analyzed the data: YJ VM TQS TMK YH WQL MF BV HN YL AP GU LG KB SLY TG TK AO IJS KM KW GG RA CC HR RB DJS XX SDI DCC DAG SJS RS LGB MAL BM RK AM. Contributed reagents/materials/analysis tools: DCC DAG SJS RS. Wrote the manuscript: YJ VM TQS TMK WQL DGP AM YH.