mtDNA T8993G Mutation-Induced F1F0-ATP Synthase Defect Augments Mitochondrial Dysfunction Associated with hypoxia/reoxygenation: The Protective Role of Melatonin

Wen-Yi Huang; Mei-Jie Jou; I. Peng Tsung

doi:10.1371/journal.pone.0081546

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Open Access

Peer-reviewed

Research Article

mtDNA T8993G Mutation-Induced F1F0-ATP Synthase Defect Augments Mitochondrial Dysfunction Associated with hypoxia/reoxygenation: The Protective Role of Melatonin

Wen-Yi Huang ,

Contributed equally to this work with: Wen-Yi Huang, I. Peng Tsung

Affiliations Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, Taiwan
⨯
Mei-Jie Jou,

Affiliation Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
⨯
I. Peng Tsung

Contributed equally to this work with: Wen-Yi Huang, I. Peng Tsung

Affiliations Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, Taiwan, Department of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
⨯

mtDNA T8993G Mutation-Induced F1F0-ATP Synthase Defect Augments Mitochondrial Dysfunction Associated with hypoxia/reoxygenation: The Protective Role of Melatonin

Wen-Yi Huang,
Mei-Jie Jou,
I. Peng Tsung

Published: November 29, 2013
https://doi.org/10.1371/journal.pone.0081546

About the Authors

Wen-Yi Huang

Contributed equally to this work with: Wen-Yi Huang, I. Peng Tsung

Affiliations Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, Taiwan

Mei-Jie Jou

Affiliation Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

I. Peng Tsung

Contributed equally to this work with: Wen-Yi Huang, I. Peng Tsung

Affiliations Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, Taiwan, Department of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WYH TIP MJJ. Performed the experiments: WYH. Analyzed the data: WYH. Contributed reagents/materials/analysis tools: WYH TIP MJJ. Wrote the manuscript: WYH TIP.

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Mitochondria
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Melatonin
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Apoptosis
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Hypoxia
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Antioxidant therapy
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Antioxidants
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Depolarization
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Medical hypoxia
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