About the Authors

Tracy J. Pritchard

Contributed equally to this work with: Tracy J. Pritchard, Yoshiaki Kawase

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Yoshiaki Kawase

Contributed equally to this work with: Tracy J. Pritchard, Yoshiaki Kawase

Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

Kobra Haghighi

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Ahmad Anjak

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio, United States of America

Wenfeng Cai

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Min Jiang

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio, United States of America

Persoulla Nicolaou

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

George Pylar

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Ioannis Karakikes

Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

Kleopatra Rapti

Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

Jack Rubinstein

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio, United States of America

Roger J. Hajjar

RJH and EJK are joint senior co-authors on this work.

Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

Evangelia G. Kranias

litsa.kranias@uc.edu

RJH and EJK are joint senior co-authors on this work.

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Competing Interests

RJ Hajjar and EG Kranias are scientific founders of Nanocor. Nanocor sponsored the following patents on inhibitor-1: Modulating phosphatase activity in cardiac cells (THE GENERAL HOSPITAL CORPORATION; University of Cincinnati) Hajjar, Roger J.; Delmonte, Federica; Kranias, Evangelia Patent Number: EP1791432 - June 2007 Patent Number: US20080125385 – May 2008 Patent Number: WO2006029319 – March 2006 Phosphatase inhibitor protein-1 as a regulator of cardiac function (University of Cincinnati) Kranias, Evangelia; Rodriguez, Patricia; Mitton, Bryan Patent Number: WO2007100465 – September 2007 Patent Number: US20090203596 - August 2009 Patent Number: EP1994043 – November 2008 Patent Number: 7989606 - August 2011. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: TJP YK KH IK KR JR RJH EGK. Performed the experiments: TJP YK KH GP PN AA WC MJ IK KR. Analyzed the data: TJP YK KH AA MJ IK KR JR RJH EGK. Contributed reagents/materials/analysis tools: PN JR. Wrote the paper: TJP YK KH RJH EGK.