About the Authors

Yosuke Shimada

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan, Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

Makoto Kinoshita

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan, Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan, Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Kazuo Harada

Affiliation Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

Masafumi Mizutani

Affiliation Morishita Jintan Co., Ltd., Osaka Techno Center, Osaka, Japan

Kazunori Masahata

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan, Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

Hisako Kayama

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan, Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan, Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Kiyoshi Takeda

ktakeda@ongene.med.osaka-u.ac.jp

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan, Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan, Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Competing Interests

Masafumi Mizutani is an employee of Morishita Jintan company. Patent number: US5478570; Patent number: US6531150. Assignee: Morishita Jintan Co., Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YS MK KT. Performed the experiments: YS KH. Analyzed the data: YS MK HK KT. Contributed reagents/materials/analysis tools: MM KM. Wrote the paper: YS MK KT.