About the Authors

Asadur Tchekmedyian

asadur@adinet.com.uy

Affiliation Gastroenterology, Pasteur Hospital, Ministry of Public Health, Montevideo, Uruguay

Christopher I. Amos

Affiliation Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, United States of America

Sherri J. Bale

Affiliation GeneDx, Gaithersburg, Maryland, United States of America

Dakai Zhu

Affiliation Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, United States of America

Stefan Arold

Affiliations Department of Biochemistry and Molecular Biology, Center for Biomolecular Structure and Function, MD Anderson Cancer Center, University of Texas, Houston, Texas, United States of America, Division of Biological and Environmental Sciences and Engineering, Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

Joaquin Berrueta

Affiliation Department of Gastroenterology, National School of Medicine, Universidad de la Republica, Montevideo, Uruguay

Natalie Nabon

Affiliation Department of Gastroenterology, National School of Medicine, Universidad de la Republica, Montevideo, Uruguay

Thomas McGarrity

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, United States of America

Competing Interests

Sherri Bale is an employee of GeneDx, a wholly-owned subsidiary of BioReference Laboratories, Inc., a public company. She owns stock in BioReference Laboratories. GeneDx provides molecular diagnostic testing for the STK11 gene in PJS. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AT CIA SJB DZ SA JB NN TM. Analyzed the data: AT CIA SJB DZ SA JB NN TM. Wrote the paper: AT CIA SJB DZ SA JB NN TM.