Potentiation of the Effect of Thiazide Derivatives by Carbonic Anhydrase Inhibitors: Molecular Mechanisms and Potential Clinical Implications

Kamyar Zahedi; Sharon Barone; Jie Xu; Manoocher Soleimani

doi:10.1371/journal.pone.0079327

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Open Access

Peer-reviewed

Research Article

Potentiation of the Effect of Thiazide Derivatives by Carbonic Anhydrase Inhibitors: Molecular Mechanisms and Potential Clinical Implications

Kamyar Zahedi,

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio
⨯
Sharon Barone,

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio
⨯
Jie Xu,

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio
⨯
Manoocher Soleimani

* E-mail: Manoocher.Soleimani@uc.edu

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio
⨯

Potentiation of the Effect of Thiazide Derivatives by Carbonic Anhydrase Inhibitors: Molecular Mechanisms and Potential Clinical Implications

Kamyar Zahedi,
Sharon Barone,
Jie Xu,
Manoocher Soleimani

Published: November 18, 2013
https://doi.org/10.1371/journal.pone.0079327

About the Authors

Kamyar Zahedi

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio

Sharon Barone

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio

Jie Xu

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio

Manoocher Soleimani

* E-mail: Manoocher.Soleimani@uc.edu

Affiliation Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MS. Performed the experiments: KZ JX SB. Analyzed the data: KZ SB. Contributed reagents/materials/analysis tools: MS KZ SB. Wrote the paper: MS.

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Urine
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Kidneys
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Diuretics
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Excretion
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Carbonic anhydrases
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Nucleotides
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Bicarbonates
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Nephrons
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