Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

Margaret Tammaro; Peri Barr; Brett Ricci; Hong Yan

doi:10.1371/journal.pone.0079202

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Open Access

Peer-reviewed

Research Article

Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

Margaret Tammaro,

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Peri Barr,

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Brett Ricci,

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Hong Yan

* E-mail: Hong_Yan@fccc.edu

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯

Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

Margaret Tammaro,
Peri Barr,
Brett Ricci,
Hong Yan

Published: November 7, 2013
https://doi.org/10.1371/journal.pone.0079202

About the Authors

Margaret Tammaro

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Peri Barr

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Brett Ricci

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Hong Yan

* E-mail: Hong_Yan@fccc.edu

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MT PB BR HY. Performed the experiments: MT PB BR HY. Analyzed the data: MT PB BR HY. Wrote the manuscript: HY.

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Recombinase polymerase amplification
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DNA replication
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Cell staining
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Synthesis phase
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Small interfering RNA
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G2 phase
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DNA transcription
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Cancers and neoplasms
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